The effects of Cardiospermum Halicacabum leaf extracts on different phases of acute inflammation were examined. Investigations were performed using different phlogistic agents-induced paw oedema viz., Carrageenan-induced paw oedema and Dextran- induced paw oedema in rats. Various extracts (ethanol and aqueous) of Cardiospermum Halicacabum leaf at a dose of 250 mg/kg and 500 mg/kg orally were tested. Diclofenac sodium at the dose of 10mg/kg was used as standard. Both the extracts showed significant activity (*p<0.05 & **p<0.01) compared with the control in both of these models. The dry powdered seeds were found to contain alkaloids, glycosides, saponins, tannins and carbohydrates. Thus it is revealed from the screening model used that the ethanol extract and aqueous fraction of this plant possesses acute anti-inflammatory activity.
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